He worked as nutrition epidemiologist for TNO-nutrition, the main Dutch research institute for nutrition-related research (1989-1991). He was granted a fellowship from the Dutch Cancer Society and worked for this Society until 1994 after which he started his PhD research at the Department of Health Education and Promotion of Maastricht University. He obtained his PhD in Health Sciences in 1997 and subsequently worked as associate professor in health psychology and later as dean of the faculty of social sciences at the Netherlands Open University. From 2000-2002 Hans Brug was professor of Nutrition Education and director of education at the Faculty of Health Sciences, Maastricht University. From 2002 to early 2007 Brug was professor of Determinants of Population Health at the Department of Public Health, Erasmus University Medical Center, Rotterdam. From 2007 to April 2012 he was the director of the EMGO Institute for Health and Care Research at the VU University Medical Center, after which he was head of division and associate dean for research.