Brenda Penninx has over 700 publications. View the publications of B.W. Penninx on the research portal VUmc:

Four key example publicatons listed per core research area:

Public Health Impact of Depression

  1. Cuijpers P, Vogelzangs N, Twisk J, Kleiboer A, Li J, Penninx BW. Comprehensive meta-analysis of excess mortality in depression in the general community versus patients with specific illnesses. Am J Psychiatry 2014;171:4.
  2. Boschloo L, Schoevers RA, Beekman AT, Smit JH, van Hemert AM, Penninx BW. The four-year course of major depressive disorder: the role of staging and risk factor determination. Psychother Psychosom 2014;83:279-88.
  3. Penninx BWJH, Guralnik JM, Leveille S, Ferrucci L, van Eijk JThM. Exploring the effect of depression on physical disability: longitudinal evidence from the Established Populations for Epidemiologic Studies of the Elderly. Am J Public Health 1999;89:1346-1352.
  4. Penninx BW, Guralnik JM, Ferrucci L, Simonsick EM, Deeg DJ, Wallace RB. Depressive symptoms and physical decline in community-dwelling older persons. Journal of the American Medical Association (JAMA) 1998;279:1720-1726.


Interaction between Mental and Somatic Health

  1. Penninx BW, Milaneschi Y, Lamers F, Vogelzangs N. Understanding the somatic consequences of depression: biological mechanisms and the role of depression symptom profile. BMC Medicine 2013;11:129.
  2. Verhoeven J, Revezs D, Epel E, Lin J, Wolkowitz O, Penninx BW. Major depressive disorder and accelerated cellular aging: results from a large psychiatric cohort study. Mol Psychiatry 2014;19:895-901.
  3. Penninx BW, Beekman AT, Honig A., Deeg DJH van Eijk JT, van Tilburg W. Depression and cardiac mortality - Results from a community-based longitudinal study. Archives of General Psychiatry 2001;58, 221-227.
  4. Penninx BWJH, Guralnik JM, Pahor M, Ferrucci L, Cerhan JR. Wallace RB, Havlik RJ. Chronic depressed mood associated with elevated cancer risk in older persons. J Natl Cancer Inst 1998;90:1888-93.


Psychiatric Genetics

  1. Jansen R*, Penninx BW*, Madar V, Xia K, Milaneschi Y, Hottenga JJ, Hammerschlag AR, Beekman A, van der Wee N, Smit JH, Brooks AI, Tischfield J, Posthuma D, Schoevers R, van Grootheest G, Willemsen G, de Geus EJ, Boomsma DI, Wright FA, Zou F, Sun W, Sullivan PF. Gene expression in major depressive disorder. Mol Psychiatry 2015; Epub.
  2. Wright FA, Sullivan PF, Brooks AI, Zou F, Sun W, Xia K, Madar V, Jansen R, Chung W, Zhou YH, Abdellaoui A, Batista S, Butler C, Chen G, Chen TH, D'Ambrosio D, Gallins P, Ha MJ, Hottenga JJ, Huang S, Kattenberg M, Kochar J, Middeldorp CM, Qu A, Shabalin A, Tischfield J, Todd L, Tzeng JY, van Grootheest G, Vink JM, Wang Q, Wang W, Wang W, Willemsen G, Smit JH, de Geus EJ, Yin Z, Penninx BW, Boomsma DI. Heritability and genomics of gene expression in peripheral blood. Nat Genetics 2014;46:430-7.
  3. Breen G, Lewis CM, Vassos E, Pergadia ML, Blackwood DH, Boomsma DI, Penninx B, Sullivan PF, Pedroso I, Collier D, McGuffin P. Replication of association of 3p21.1 with susceptibility to bipolar disorder but not major depression. Nat Genet 2011;43:3-5.
  4. Sullivan P, de Geus EJC, Willemsen G, James MR, Smit JH, Zandbelt T, Arolt V, Baune BT, Blackwood D, Cichon S, Coventry WL, Domschke K, Dumenil T, Farmer A, Fava M, Gordon SD, Heutink P, Holsboer F, Hoogendijk WJ, Hottenga JJ, Kohli M, Lin D, Lucae S, MacIntyre DJ, Maier W, McGhee KA, McGuffin P, Montgomery G, Muir WJ, Nolen W, Nöthen MM, Perlis R, Pirlo K, Posthuma D, Rietschel M, Schosser A, Smoller JW, AB Smit, Tzeng JY, van Dyck R, Zitman FG, Verhage M, Martin NG, Wray NR, Boomsma DI, Penninx BW. Genome-wide association for Major Depressive Disorder: a possible role for the protein PCLO. Mol Psychiatry 2009;14:359-75.


    Pathophysiology of Depression

  1. Vreeburg SA, Hoogendijk WJ, van Pelt J, de Rijk RH, Verhagen JCM, van Dyck R, Smit JH, Zitman FG, Penninx BW. Major Depressive Disorder and Hypothalamic-pituitary-adrenal axis activity: Results from a large cohort study. Archives of General Psychiatry 2009;66:617-626.
  2. Lamers F, Vogelzangs N, Merikangas KR, de Jonge P, Beekman AT, Penninx BW. Evidence for a differential role of HPA-axis function, inflammation and metabolic syndrome in melancholic versus atypical depression. Mol Psychiatry 2013;18:692-9.
  3. Licht CM, de Geus EJ, Zitman FG, Hoogendijk WJ, van Dyck R, Penninx BW. Association between major depressive disorder and heart rate variability in the Netherlands Study of Depression and Anxiety (NESDA). Arch Gen Psychiatry 2008;65:1358-67.
  4. Penninx BWJH, Kritchevsky SB, Yaffe K, Newman AB, Simonsick EM, Rubin S, Ferrucci L, Harris T, Pahor M. Inflammatory markers and depressed mood in older persons: results from the health, aging and body composition study. Biol Psychiatry 2003;54:566-72.


Treatment of Depression

  1. Schmaal L, Marquand AF, Rhebergen D, van Tol MJ, Ruhé HG, van der Wee NJ, Veltman DJ, Penninx BW. Predicting the Naturalistic Course of Major Depressive Disorder Using Clinical and Multimodal Neuroimaging Information: A Multivariate Pattern Recognition Study. Biol Psychiatry, Epub
  2. Vogelzangs N, Beekman AT, van Reedt Dortland AK, Schoevers RA, Giltay EJ, de Jonge P, Penninx BW. Inflammatory and metabolic dysregulation and the 2-year course of depressive disorders in antidepressant users. Neuropsychopharmacology 2014;39:1624-34.
  3. Licht CM, Penninx BW, de Geus EJ. Effects of antidepressants, but not psychopathology, on cardiac sympathetic control: a longitudinal study. Neuropsychopharmacology.2012;37:2487-95.
  4. Penninx BWJH, Rejeski J, Messier SP, Pandya J, Miller M, DiBari M, Applegate W, Pahor M. Exercise and depressive symptoms: A comparison of aerobic and resistance exercise effects on emotional and physical function in older persons with high and low depressive symptomatology. J Gerontol: Psych Sci 2002;57:P124-P132.