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After studies and training in clinical psychology in Italy, Yuri Milaneschi (1978)  worked in the field of epidemiology of aging in Italy (2007-2010) and USA (National Institute of Aging, 2010-2012). He combined these two perspectives in his major research theme: the study, using the tools of epidemiology, of biological pathways that may have a role in the pathophysiology of depression. In 2012 he became Post-Doc at the department of Psychiatry of VUMC, developing the investigation of the biological pathways previously identified in a cohort including clinically depressed patients (The Netherlands Study of Depression and Anxiety). Moreover, he embraced the developments of the genomics era, expanding his research questions beyond the study of biomarkers of depression toward its genetic basis.