Development of a non-invasive test to diagnose obstructive hydronephrosis among newborns


Starting date: 00/00/2008 Obstruction of the pyelo-ureteral-junction, i.e. UPJ-obstruction, causes hydronephrosis and loss of kidney function. In general, hydronephrosis is detectable by ultrasound. Using ultrasound, antenatal hydronephrosis is diagnosed in 1 out of 500 newborns. It will disappear spontaneously in a large number of children during the first years of life without causing harm to the kidney. A concise follow-up of all children with hydronephrosis with calyceal dilatation results in selection of those children who need operative treatment because of UPJ-obstruction. Follow-up is based on kidney ultrasounds and bothersome and invasive MAG-III diuretic renograms. We need a non-invasive, more reliable and rather simple test, or biomarker, to diagnose UPJ-obstruction reducing the burden of tests for newborns and their parents.