Predictors of corneal transplantation outcomes regarding visual functioning, quality of life, psychological well-being and participation (WC2017-012)


Starting date: 01/09/2017

Corneal diseases are a common cause of blindness, affecting an estimated 4.9 million people worldwide. Corneal transplantation is the most effective treatment for advanced corneal disease. A corneal transplantation may have a positive impact on objective and subjective outcome measures. A successful corneal transplantation may result in partial or full recovery of sight and prevention of blindness. Clinical outcome measures may be both objective and accurate in assessing corneal function, however, it does not adequately describe the impact of a corneal transplantation on a patient’s quality of life and on a patient’s ability to undertake activities of daily and social living. While a corneal transplantation technically could be successful and objective outcome measures show good results, visual functioning, quality of life, psychological well-being and participation of patients may still be restricted because of residual problems. Nowadays, patient-reported outcome measures (PROMS) are more frequently used as indicator for quality of care. Also for health insurances, the patients’ perspective get a more prominent position in evaluating the quality of care. However, until now, most studies have focused on objective clinical outcomes of corneal transplantation. Studies to the effect of corneal transplantation on quality of life and other subjective outcomes are limited in number. Those studies are often retrospective, have a small sample size, only describe short-term results, or do not take into account prognostic factors of corneal transplantation outcomes.