Physical Activity and Dietary intervention in OVArian cancer (PADOVA): a RCT evaluating effects on body composition, physical function and fatigue (WC2017-004)


Starting date: 01/01/2017

As a consequence of the disease and its treatment, many women with ovarian cancer perceive physical and psychological problems compromising their quality of life. Physical activity and diet are energy balance related behaviours linked to body composition and have been associated with improved physical function and quality of life, as well as reduced fatigue. In addition, regular physical activity, a healthy diet and body weight have been associated with increased survival. Current knowledge on the effect of physical activity and dietary interventions on health outcomes generally relies on studies among women with breast cancer  treated with curative intent. Except for a few pilot studies indicating that lifestyle interventions are safe and feasible, no studies have focused on women with ovarian cancer. Ovarian cancer has a very distinct disease and treatment trajectory as it is often detected at an advanced stage. It is not known whether findings from studies among women with breast cancer are generalizable to women with ovarian cancer, thus a well-designed randomized controlled trial is needed.           
We hypothesize that women who receive a combined exercise and dietary intervention during chemotherapy have a more favourable body composition, better physical function and fitness, lower fatigue, and fewer symptoms resulting in a higher quality of life after completion of chemotherapy compared to women not receiving a combined intervention.