Use of IPD meta-analysis to inform effective management of spinal manipulative therapy for patients with chronic low back pain (WC2015-045)


Starting date: 13/07/2015

Background: Low back pain (LBP) is a leading cause of pain and disability and as a result has a major socioeconomic impact. The majority of the cost associated with LBP is generated by a small percentage of patients whose condition proceeds to chronicity. For chronic LBP spinal manipulative therapy (SMT) is one of several interventions which evidence suggests is moderately effective. In 2011, a Cochrane review was conducted which  investigated the effectiveness of SMT for chronic low back pain. However, one of the problems with traditional meta-analyses is the use of aggregate (mean) data while the use of individual patient data (IPD) allows for a better interpretation of the effects in select subgroups.