NESDO: the Netherlands Study on Depression in Older persons (WC2005-045)


Starting date: 01/04/2006 Depression is common in all ages and carries an enormous disease burden. As compared to depression at younger age, late-life depression has been suggested to have a largely different symptom profile and etiology with a more prominent role for apathy, cognitive dysfunction, frailty-associated processes, social losses, and specific neurobiological abnormalities. Also, late-life depression has been hypothesized to have a more chronic course, higher relapse rates, and more subsequent adverse effects on somatic health, cognitive decline and mortality. However, differences in the concept, course and consequences of depression have seldomly been directly compared between younger and older adults within a similar study design and with comparable instruments. Knowledge about the adequacy of these postulated differences between early-life and late-life depression is important, since it will yield important implications for mental health care practice and research. NESDO collaborates with the Netherlands Study on Depression and Anxiety (NESDA), a multi-site naturalistic cohort study designed to examine the long-term course and consequences of depressive and anxiety disorders in adult persons (
NESDO is financed by two Dutch organisations; 'Stichting Nuts Ohra' and 'Stichting tot Steun VCVGZ'.