Genetic and Lifestyle Origins of inflammation in Depression (GLOID) (WC2015-047)

Background

Starting date: 11/08/2015

Depression produces substantial societal costs. Its cause is unknown and treatments are suboptimal. Inflammation may be involved in depression. People with depression have elevated levels of inflammatory mediators in the blood, although it is unclear whether the source is genetic, environmental, or some interaction. A likely environmental source is unhealthy lifestyle behaviours.

To progress the field, studies must more directly test the causal status of the inflammatory hypothesis of depression; specifically, whether inflammation-related genetic polymorphisms or whole polygenic risk scores interact with unhealthy lifestyle in depression and its remission.

Providing evidence for the contribution of genetics, inflammation and unhealthy lifestyle to depression will provide opportunities for identifying people at risk of depression, treating depression, and developing individual and public health prevention strategies.