MOTAR study: MOod Treatment with Antidepressants or Running (WC2011-041)

Background

Starting date: 01/01/2012

MOTAR study: MOod Treatment with Antidepressants or Running

Treatment with an SSRI antidepressant or exercise training have both shown effectiveness in depression and anxiety care but are seldom compared in one trial. Further, whether the influence of these interventions on physiological processes and general health are comparable is unknown. The current study builds on the novel hypothesis that depression and anxiety are associated with an accelerated process of cellular aging and metabolic stress causing general health decline resulting in multiple degenerative somatic conditions. Suggestions exist that – like depression and anxiety – cellular aging and metabolic stress are reversible processes. The MOod Treatment with Antidepressants or Running (MOTAR) study is a multi-center randomized clinical trial to examine whether depression and anxiety treatment reduces physiological stress.

The findings of this trial are expected to provide detailed information about the relationship between treatment of depression and/or anxiety and the reduction of physiological stress, which contributes to a better understanding of the biological accomplishments of the two treatment regimens.