The new Hoorn Study: prevalence and determinants of impaired glucose regulation

Methods

Study desing
Cohort study 

Study population 
A random sample of 6180 men and women, aged 40-65, was drawn from the municipal registry of Hoorn; of whom 2807 agreed to participate. 

Study procedure
All participants visited the Diabetes Research Centre in Hoorn in a fasting state. The following procedures were assessed during this visit: 

-  Anthropometry (height, weight, waist circumference and hip circumference) and blood pressure measurement 

- A 2-point Oral Glucose Tolerance Test (OGTT) , with blood draws at 0 en 120 minutes after glucose ingestion.  Blood samples of both time points were used for determination of plasma glucose. In addition, from the fasting blood sample, triglycerides,total and HDL-cholesterol and HbA1c were determined. 

- Habitual physical activity (SQUASH), food consumption (Voedselvragenlijst, Universiteit Wageningen), smoking, alcohol intake, employment, education, marital status, current medication use, disease history, family history of disease, depression (CES-D), anxiety (HADS), perceived general health (SF-36), and self-reported birth weight were determined using questionnaires.

- All participants also gave written informed consent to collect data on morbidity and mortality from their medical records in the future.