Assessment of the heritability of different aspects of betacell function in normoglycaemic monozygotic and dizygotic twins

Results

 We expect to gain insight into the differential genetic and environmental contribution to the various components of ß-cell function, which may enable a more targeted approach for metabolic research in the aetiology of type 2 diabetes. Secondly, we hope to identify endophenotypes (measurable components that link disease and genotype) related to  ß-cell function, that will increase the power of future genome searches for type 2 diabetes and will led to new insights for prevention.