Meal-related hypertriglyceridaemia and low-grade inflammation in relation to betacell function in the general population

Methods

 200 men and women, aged 40-65 years were included in the study. All participants recieved a standard 75 g OGTT and a standardised mixed meal test, on separate days, to assess both beta-cell function and insulin sensitivity. Mathematical modelling of glucose, insulin and C-peptide levels was used to determine beta-cell glucose sensitivity, rate sensitivity and potentiation. The relationship of measures of insulin sensitivity and insulin secretion (beta-cell function) based on a meal tolerance test and OGTT will be characterized, as will the association of such measures with fasting and post-prandial triglyceride and free fatty acid levels.